Corresponding Author's : Lakshmi Pasricha Sarin

Co-Author's : Sadhna Jain, Ridhi Pandey, Himani Sareen, Deepika Pant, Sabika Ali, Meghna Birla

Abstract :

The use of caffeine as a psychotropic and medicinal drug has been in existence since the 19th century. It is a natural plant alkaloid used extensively all around the world. In recent years, caffeine has been incorporated into scads of products encompassing food, cosmetics, medicine and several other industries. In this review, we have accentuated the chemistry of caffeine, its metabolism and processing in the body, mechanism of action and several other effects on bodily and cognitive functions. With substantial antioxidants, caffeine is utilized in numerous ailments, including cancer, and is known to enhance longevity. The effect has also been reported in neurodegenerative disorders, anxiety, cardiovascular health, diabetes, and many other significant afflictions. As caffeine is a non-selective antagonist of adenosine receptors, it binds to such receptors and prevents us from being in a torpid state. This further helps to augment alertness and cognitive functions. Caffeine’s role in weight loss, kidney dysfunction, and its hepatoprotective and neuroprotective effects have also been emphasized. A fragment of our review also apprises an introduction to decaffeinated coffee, which is transpiring as a sought-after drink. Owing to its extensive use, high caffeine intake may induce “caffeinism” which could be life-threatening. This makes it crucial to comprehend caffeine toxicity and shed light on some of the treatments used. We also scrutinized some gaps in the literature, which could ameliorate the current research and pave the way for novel effects and efficacy of caffeine.

Keywords :

Caffeine, Metabolism, Caffeinism, Antioxidants, Cardiovascular Disease, Neurodegenerative Disorders, Decaf, Diabetes, CYP1A2

Article Details

Unique Paper ID: 41

Publication Volume & Issue: VOLUME 2 , ISSUE 2

Page(s): 31-43

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